Studies of lung cancer genome have shown that several genes are likely to be key mediators of tumor initiation and progression, including genes such as EGFR, FGFR1 and 2, ALK, RET, KRAS, NOTCH1, TP53, SOX and many more, together with activating enhancer-binding protein 2 (AP-2) and the transcription factor (TF) gene family (TFAP2). This evidence concerns the gene TP53 and lung cancer.