In another report, SIRT6 has been shown to mediate the tumor-promoting effect of NAD(P)H:quinone oxidoreductase 1 (NQO1) on hepatocellular carcinoma through the activation of AKT serine/threonine kinases in PLC/PRF/5 and Huh7 cell lines and an orthotopic tumor cell implantation mouse model [98]. This evidence concerns the gene SIRT6 and neoplasm.