NFE2L2 and alcohol dependence: In addition, SIRT6 can also activate NFE2-like BZIP transcription factor 2 (NFE2L2, commonly known as NRF2) by deacetylation to ameliorate alcohol-associated liver injury, and ginsenoside Rc, a major active ingredient of ginseng, can protect from ALD by the activation of the SIRT6-NRF2 defense axis [53].