Myeloid-specific Sirt6 knockout mice exhibit worse systemic insulin resistance and glucose intolerance, heavier liver weights, higher hepatic triglyceride and cholesterol levels, higher hepatic macrophage infiltration, and higher nonalcoholic fatty liver disease (NAFLD) activity scores than their WT counterparts after 16 weeks of high-fat diet feeding [86]. Here, SIRT6 is linked to Glucose intolerance.