Since the development of a rodent model of hydrops [2,11,12,13,14], it has been believed that vasopressin may also actively participate in Ménière’s disease pathogenesis by altering the endolymph water flow in the inner ear, through involving vasopressin receptor 2 (V2R) and aquaporin 2 (AQP2) [11]. The gene discussed is AQP2; the disease is edema.