In addition, there was a significant difference in the cell numbers between sham-EE and stroke-EE groups (sham-EE Mdn = 3.827 EdU+NeuN+ cells; IqR = 544; MCAO-EE Mdn = 5.572 EdU+NeuN+ cells; IqR = 640; U = 0.00; n = 14; p = 0.002), as well as between the stroke animals due to the different housing conditions (p = 0.003) (Figure 5A,B). The gene discussed is RBFOX3; the disease is stroke disorder.