In line with this, UCH-L1 has been suggested as a possible biomarker for several types of CNS damage and disease, including ischemic brain injury, strokes, epileptic seizure, traumatic and spinal cord injury [78] as well as PD and atypical parkinsonian disorders (APD), in which UCH-L1 levels in the cerebrospinal fluid were decreased [122]. This evidence concerns the gene UCHL1 and brain injury.