RIPK3 and bacterial infectious disease: During Staphylococcus aureus superinfection following IAV infection, the levels of CYP450 metabolites, which are PPARα ligands, increase significantly and trigger receptor-interacting serine/threonine-protein kinase 3 (RIPK3)-induced necroptosis, thus exacerbating the lung pathology and increasing mortality from secondary bacterial infection [101].