Furthermore, Liu et al. investigated the effect of a bioactive food compound on preeclampsia in placental explant cultures and RUPP rat model, and demonstrated that procyanidin B2 induced PPARγ expression, thus inhibiting sFLT1 expression via the nuclear factor erythroid 2-related factor 2 (Nrf2)/PPARγ axis [104]. This evidence concerns the gene PPARG and preeclampsia.