PPARG and fetal growth restriction: On the contrary, Holdsworth-Carson et al. showed that placental PPARγ mRNA and protein were significantly increased in placentae from women that delivered preterm with co-existing intrauterine growth restriction and preeclampsia [83], while Jia et al. noted high PPARγ protein expression levels in preeclamptic placental tissues, with the rs201018 polymorphism in the PPARγ promoter region significantly correlating with the development of preeclampsia [96].