SP1 and preeclampsia: Of note, placental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) and specificity protein 1 (Sp-1) protein levels were positively associated with PPARγ [82], omega-3 fatty acid supplementation promoted PPARγ protein expression in late-onset preeclampsia [88], PPARγ expression positively correlated with the epigenetic modification via trimethylated lysine 4 of the histone H3 (H3K4me3) and acetylated lysine 9 of the histone H3 (H3K9ac) [91], while PPARγ was negatively associated with micro-RNA-27b-3p and showed good predictive value on preeclampsia [94].