PLAU and Hyperglycemia: Hyperglycemia enhances PPARγ pathways, thus diminishing the human cytotrophoblast invasion, increasing interleukin-6 and soluble fms-like tyrosine kinase-1 (sFIt-1), as well as inhibiting urokinase plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1) [62].