PPARG and preeclampsia: Moreover, Nema et al. showed that placental PPARγ levels were significantly lower in Vitamin D-deficient than in Vitamin D-supplemented female rats with preeclampsia [106], while Ueki et al. concluded that plasma from Catechol-O-Methyltransferase (COMT)-deficient pregnant mice exhibited low PPARγ transcriptional activity, and correlated with elevated angiotensin II receptor type 1 (AT1R) levels [107].