Other than mouse models, microcephaly has also been demonstrated in the cerebral organoids developed from CDK5RAP2 and ASPM mutated patient-derived induced pluripotent stem (iPS) cells, which indicated premature neuronal differentiation as a pathomechanism for the former gene and impaired neuronal functions (due to defective lamination), as well as decreased neural progenitor pool for the later gene [106,107]. Here, CDK5RAP2 is linked to microcephaly.