Authors modeled both hypomorphic and null mutations of NUP107 in zebrafish by CRISPR/Cas9-mediated genome editing and showed that truncating mutation (c.50_56del7; p.Thr81Argfs*74) causes early lethality and developmental defects including microcephaly, whereas in-frame hypomorphic mutation (c.137_139del; p.Ala46del) was compatible with embryonic survival and did not cause any obvious phenotype [73]. This evidence concerns the gene NUP107 and microcephaly.