This argument is elegantly supported by establishing the genotype–phenotype correlation of different components of the nuclear pore complex, p37, NUP107, and NUP133, which showed phenotypic variability in microcephalics; it was intriguing to observe that patients segregating a hypomorphic NUP37 mutation did not show any symptoms of steroid-resistant nephrotic syndrome (SRNS), which was diagnosed only in the individuals segregating the NUP107 loss-of-function variant [73]. Here, NUP107 is linked to steroid-resistant nephrotic syndrome.