In a comprehensive targeted sequencing-based study analyzing almost 1000 primary breast cancer samples, CBFB was shown to be one of the top 17 recurrently mutated genes [175], whilst a separate whole-genome sequencing study of 560 breast tumors identified CBFB as one of the 93 protein-coding genes harboring potential driver mutations [11]. The gene discussed is CBFB; the disease is breast carcinoma.