The Runt-related transcription factor (RUNX) family, historically known as the polyoma enhancer-binding protein 2 α (PEBP2α), acute myeloid leukemia (AML) and core binding factor α (CBFα) family of proteins [25], comprises three members: RUNX1, RUNX2 and RUNX3. The gene discussed is RUNX2; the disease is acute myeloid leukemia.