KMT2A and Global developmental delay: For example, while KDM5C is an H3K4me eraser, KMT2A is an H3K4me writer, and KMT2A haploinsufficiency is associated with the NDD Weidemann–Steiner Syndrome (WDSTS) characterized by intellectual disability, developmental delay, hairy elbows, and short stature in both males and females [32,33].