In a more recent study by Carlsten et al., the downregulation of NKG2D and DNAM-1 expression in bone marrow-derived NK cells from MDS patients was reportedly associated with elevated blast counts and high-risk disease, but similar to Kiladjian et al. they did not see receptor changes in the surface of NK cells from peripheral blood [21]. The gene discussed is CD226; the disease is myelodysplastic syndrome.