In vitro data from the use of the irradiated K562 cell line modified to express membrane bound IL-15 and 41BB ligand (K562-mbIL15-41BBL) has shown a 26-fold expansion of NK cells and powerful antileukemic activity, with the ability to eradicate AML in mouse models [100,101,102]. This evidence concerns the gene IL15 and acute myeloid leukemia.