Based on the critical role of HLA-G in the immune response and on the associations previously reported between HLA-G polymorphisms and diverse autoimmune conditions, our group previously evaluated associations with the whole HLA-G locus with vitiligo in the Brazilian population, being observed for the first time an association between the rs9380142 SNP (+3187G) located in 3′UTR (untranslated region) and disease risk [19]. This evidence concerns the gene HLA-G and vitiligo.