CXCL8 and neoplasm: Tumor secretomes support the pro-tumorigenic processes via interleukins, including IL-6 and IL-8, members of the transforming growth factor (TGF) family, such as TGFβ, and secreted enzymes, such as matrix metalloproteinases (MMPs), capable of degrading the extracellular matrix (ECM), which together enable tumor cell migration and invasion.