GPNMB and hepatocellular carcinoma: Secretome analysis of the conditional medium (CM) of cultured CAFs derived from HCC specimens indicated deregulations in TGFβ-regulated secreted proteins, including semaphorin 7A (SEM7A), complement C1q tumor necrosis factor-related protein 3 (C1QT3), protocadherin gamma subfamily (PCDGK), glycoprotein nmb (GPNMB), and myoferlin (MYOF) [54].