Moreover, genetic categories of MDS with mutated SF3B1 (VAF ≥10%) and MDS with multihit TP53 (defined as two distinct TP53 mutations (each VAF ≥ 10%) or as a single TP53 mutation with either a 17p deletion on cytogenetics, a VAF of ≥ 50%, or a copy-neutral LOH at the 17p TP53 locus) have been introduced. The gene discussed is TP53; the disease is myelodysplastic syndrome.