In a different mouse model of wet AMD, phosphorylated ERK1/2, JNK, and p38 were all found to be upregulated [35], while in yet another mouse model of laser-induced choroidal neovascularization, JNK inhibition led to a decrease in apoptosis, decrease in VEGF expression, and a reduction in neovascularization [36]. Here, MAPK8 is linked to wet macular degeneration.