EGFR and hepatocellular carcinoma: Likewise, the EGFR protein expression also was significantly decreased by Curcumin (rHuh-7, 0.88; rPLC; 0.84) and the combination treatment (rHuh-7, 0.78; rPLC, 0.70; Figure 6B) compared to a non-treated group, suggesting that Curcumin-mediated suppression of EGFR might be one of the mechanisms for sensitizing Lenvatinib-resistant HCC cells.