FGF23 and heart disorder: Furthermore, another link was discussed between renal function, vascular calcification, and FGF23 expression in heart disease patients [49] The presence of vascular FGF23, FGFR1, FGFR3, and α-klotho in both the tunica intima and media characterizes calcification areas co-localized interestingly, with inflammatory macrophages [49].