Given the observed occurrence of classical Hodgkin lymphoma in the wake of half of all reported Ophelia syndromes and reports of additional cases of classical Hodgkin lymphoma with preceding paraneoplastic symptoms before [78,79,80,81], we believe it is possible that mGluR5 expression on classical Hodgkin lymphoma cells not only drives tumor progression but also plays a role in triggering anti-mGluR5 encephalitis early during tumor development, long before classical Hodgkin lymphoma is clinically detected. This evidence concerns the gene GRM5 and neoplasm.