In the other classical Hodgkin lymphoma cell lines, either no distinct subpopulation of double-positive cells was found (L-428, HDLM-2), or the subpopulation was barely visible and the percentage of mGluR5+|CD30+ cells was significantly lower (below 6% for L-540, KM-H2, and SUP-HD1) (Figure 3F, Supplementary Figure S3). This evidence concerns the gene TNFRSF8 and Hodgkins lymphoma.