Both populations were unchanged with respect to CD45 + CD4+ and CD45 + CD8+ cells in cardiac tissue, perhaps because although T cells increase in models that directly cause cardiac injury such as coronary artery ligation and myocardial infarction, it has been reported that the increase in TCD4+ and TCD8+ lymphocytes in the heart results from a wide spectrum of possible causes depending on the context of activation and the timing of the responses [21,39]. This evidence concerns the gene CD4 and myocardial infarction.