In particular, it is of interest to note that XPC (Xeroderma Pigmentosum group C) is a DNA repair protein interacting with the NER (nucleotide excision repair) mechanism and could play a role in the pathogenesis of CML via its genetic polymorphisms [41,42]. This evidence concerns the gene XRCC6P5 and chronic myelogenous leukemia, BCR-ABL1 positive.