MAPT and behavioral variant of frontotemporal dementia: However, these conclusions need to be further investigated because another study analyzed progranulin concentrations in CSF of the different FTD subtypes and found levels to be significantly lower in semantic dementia and bvFTD compared to progressive non-fluent aphasia (PNFA) and controls, indicating that CSF-progranulin might represent a promising biomarker for TDP-mediated FTD instead of tau-mediated FTD [155].