FCGR3A and autoimmune disease: Aberrations in this gene are associated with increased susceptibility of recurrent viral infections, autoimmune disease systemic lupus erythematosus, etc. Interestingly, the action of drug rituximab, a monoclonal antibody (anti-CD20), is based on the ADCC mechanism, and the presence of the missense mutation (rs396991) is associated with increased affinity of FCGR3A for IgG.