For example, GCB cell lines OCI-LY1 and WSU-DLCL2 shared mutations in BCL2, EZH2, deletion/inversion of PTEN, and FOXO3/PDGFD translocations, and these cell lines may possibly follow a similar course (e.g., PI3K-AKT signaling) to DLBCL tumorigenesis because of their shared genetic profile. The gene discussed is EZH2; the disease is diffuse large B-cell lymphoma.