BIRC5 and cancer: Beyond CP-DN-ATF5, Zhou et al. [168] showed that survivin protein levels are profoundly depleted in T98G and additional cancer lines after exposure to Dpep and Bpep, while Darvishi et al. [169] reported that ST101 downregulates BIRC5/survivin mRNA and protein in U251 GBM cells and, like CP-DN-ATF5, appears to promote proteasomal degradation of the protein.