MAPK3 and schizophrenia: In addition, the C704 allele has been associated with reduced activity of extracellular signal-regulated kinase 1 (ERK1) and serine/threonine kinase RAC-alpha (AKT) (Figure 2), altered DISC1 binding affinity for NDE1 and NDEL1, and a change in DISC1 oligomeric status [206,244,250,251], relevant for schizophrenia.