SHANK2 and schizophrenia: Some authors have pointed out that chronic treatment with mood stabilizers, lithium, or valproate, used clinically as antipsychotic augmentation strategies in schizophrenia, can directly affect the expression of Homer1b/c and related Shank and inositol 1,4,5 trisphosphate receptors (IP3Rs) in cortical and subcortical regions [20,104].