ERBB4 and Anxiety: Specifically, the NRG1/ErbB4 pathway was seen to interact with PSD-95 and NMDAR, and that chronic administration of MK-801, induced a short-term potentiation of the functional interaction between NRG1/ErbB4 and NMDAR in the PFC and hippocampus of the rat, along with anxiety-like behavioral abnormalities, providing further evidence for cross-talk between the two signaling pathways [79].