The bidirectional interconnection between PSD-95 and stargazin mediates the targeting of AMPARs to the synaptic membrane, and, therefore, it is conceivable that a functional link between NMDARs and AMPARs occurs via the PSD-95-stargazin complex, potentially dysregulated in the pathophysiology of schizophrenia. This evidence concerns the gene CACNG2 and schizophrenia.