Reduced gray matter in the superior frontal gyrus, anterior cingulate cortex, and left supramarginal gyrus was found in F607 allele carriers compared with L607 homozygotes, as well as suffering from more severe positive symptoms in schizophrenia, providing a potential mechanism by which DISC1 could confer an increased risk for schizophrenia [239,240]. Here, DISC1 is linked to schizophrenia.