A principal implication of Homer1 in cellular signaling is the modulation of glutamatergic transmission mainly related to mGluR type I, due to the role of glutamate in schizophrenia pathophysiology makes the Homer1 family of potential relevance both for the structure and function of the dendritic spine at a glutamatergic synapse (Table 1). Here, HOMER1 is linked to schizophrenia.