Hypoxia significantly increased binding and uptake of [177Lu]Lu-PSMA in MCF-10A (0.3% vs. 3%) and MDA-MB-231 (0.4% vs. 3.4%), whereas the PCa cells LNCaP showed decreased uptake under hypoxia (19% vs. 6.7%) (Figure 5B). The gene discussed is FOLH1; the disease is posterior cortical atrophy.