Based on a study using neuroblastoma-derived cell lines, even the transactivation deficient mutant form of RUNX3 promotes ubiquitination and protein degradation of MYCN, suggesting that RUNX3 might recruit an E3 ubiquitin ligase of MYCN in a transactivation-independent manner (Figure 1C and Figure 4). The gene discussed is RUNX3; the disease is neuroblastoma.