RUNX3 and adenocarcinoma: Of relevance to this, disruption of Runx3 by intranasally infecting Runx3f/f mice with adeno-Cre induces adenomas (AD) in the lung and accelerates KrasG12D-driven adenocarcinoma (ADC) development as effectively as loss of p53, indicating that loss of RUNX3 is sufficient to override the effect of KRAS/oncogene-induced senescence in AD formation [84].