Previously, we reported that TAp63, which is one of the isoforms of p63 containing the N-terminal transcriptional activation domain, has the ability to repress transcription of the MYCN and NCYM genes; the latter being a cis-antisense gene of MYCN responsible for stabilizing MYCN protein and accelerating distant metastases in neuroblastoma (Figure 2). This evidence concerns the gene MYCN and neuroblastoma.