As mentioned earlier, considering that ΔNp73 inhibits neuronal programmed cell death by blocking the pro-apoptotic function of p53 [45], DNA damage by a chemotherapeutic agent or decreased expression levels of RUNX1 may confer ΔNp73-mediated anti-apoptotic ability on neuroblastomas that express wild-type p53. Here, RUNX1 is linked to neuroblastoma.