Endothelial integrity in the murine LPS-induced ARDS model could also be preserved by using SU5416, a potent and selective vascular endothelial growth factor receptor (VEGFR) inhibitor, which blocked the VEGF/VEGFR and TLR4/NF-kappaB signaling pathways [64]. The gene discussed is KDR; the disease is acute respiratory distress syndrome.