Using immunoassay, they found that plasma Insulin-like Growth Factor Binding Protein 7 (IGFBP7) moderately increased ARDS 28-day mortality (OR 1.11, 95% CI 1.04–1.19, p = 0.002) per log2 increase (i.e., per two-fold increase). This evidence concerns the gene IGFBP7 and acute respiratory distress syndrome.