An index combining the levels of four proteins (β2-microglobulin >3.7 mg/L, VCAM1 >2216.8 ng/mL, ApoC3 ≤54.532 μg/mL, ApoE >62.45 mg/L) and two conventional infection biomarkers (procalcitonin, C-reactive protein yielded an AUC of 0.772 for sepsis identification. Here, APOE is linked to Sepsis.