MYH14 and cancer: The mechanisms contributing to cancer-associated changes in actin–myosin organization include cell-intrinsic factors, such as genetic or epigenetic alterations that affect the expression and/or activity of cytoskeleton regulators or structural components, as well as cell-extrinsic influences, including receptor ligands and the physical tumour microenvironment, which stimulate signal transduction pathways that culminate in changes in cytoskeleton organization [5].