CDC42BPA and central nervous system cancer: Furthermore, microarray analysis of gene expression in glioma patients revealed increased Cdc42BPA mRNA expression relative to normal brain tissue, while immunohistochemical analysis with an antibody that recognized the active autophosphorylated Ser1003 of MRCKα determined that there was elevated kinase activity on tumour margins relative to tumour cores, consistent with increased invasion of glioma cells away from the tumour’s edges [42].