Three studies have analyzed the impact of IF in atherogenesis in atherosclerosis mouse models, apolipoprotein E- and low-density lipoprotein receptor-deficient mice (Apoe-/- and LDLr-/-, respectively) [22,23,24], but they included only males, and the differences in the diet compositions and IF regimen patterns used in these studies have yielded contradictory results regarding glucose homeostasis and atherogenesis. This evidence concerns the gene APOE and atherosclerosis.