It also resulted in a boost in the expression of granzyme B, perforins, IFN-γ, and TNF-α in TILs, as well as an increase in the phagocytosis of tumor cells by tumor-associated macrophages in a melanoma xenograft model treated with serine/threonine-protein kinase B-raf (BRAF) and mitogen-activated protein kinase kinase (MEK) inhibitors [264]. This evidence concerns the gene PRF1 and melanoma.