While Tencerova and collaborators (2019) found that LepR+ bone marrow-MSCs from patients with obesity are associated with accelerated senescence and bone fragility [114], Li’s group showed that human MSCs differentiated toward osteogenic lineage in the presence of leptin had an increased ALP activity, compared with untreated cells [115]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.