↓ Tissue triglyceride content, ↓ cells showing ballooning necrosis, ↓ fibrosis in cells in mice NASH model treated by IGF-1(ballooning necrosis cell number/HPF reduced by circa 50%; tissue triglyceride reduced approximately by 20%)IGF-1-induced cellular senescence of HSCsIGF-1 treatment in the NASH mouse model induced a decrease in the expression of activated markers for HSCs (relative mRNA αSMA reduced by approximately 60%) p53 is necessary for the IGF-I-induced senescence in HSCs. The gene discussed is TP53; the disease is metabolic dysfunction-associated steatohepatitis.