Moreover, IGFBP6 and IGFBP7 had a strong positive relationship with NAS (r = 0.47, p < 0.004; r = 0.83, p < 0.0001), fibrosis stages (r = 0.15, p< 0.04; r = 0.25, p < 0.0001), and liver enzymes (ALT-IGFBP6 r = 0.34, p > 0.04; ALT-IGFBP7 r = 0.60, p > 0.0001; AST-IGFBP6 r = 0.33, p > 0.05; AST-IGFBP7 r = 0.64, p < 0.0001) [30]. Here, IGFBP7 is linked to neonatal abstinence syndrome.