↓ Hepatic IGF-1 expression in individuals with higher grades of steatosis and higher NAS scores.↓IGFBP2 and IGFBP4 (r = −0.49; r = −0.12) and ↑ IGFBP6 and IGFBP7 (r = 0.25; r = 0.35) with increasing steatosis Reduction of IGFBP2 after tesamorelin was associated with lower NAS score (r = 0.35) and hepatocellular ballooning grade (r = 0.37), but not with changes in lobular inflammation grade (r = 0.17)GHRH increased circulating IGFBP-1 and IGFBP-3 but decreased IGFBP-2 and IGFBP-6. This evidence concerns the gene IGFBP4 and steatosis.