↓ IGF-1 mRNA in patients with NASH when compared to patients with simple steatosis (approximative reduction of 66%). Among the 15 NASH patients, IGF-1 expression was characterized by an inverse relation to the grade of inflammation, but no statistical significance was found.GHR mRNA levels were comparable in patients with NASH and simple steatosis. This evidence concerns the gene GHR and metabolic dysfunction-associated steatohepatitis.