IGF1 and steatosis: ↑ Liver triglyceride content (9 mg/g vs. 1mg/g)↑ Serum AST and ALT, steatosis, and hepatic cell injury in GH-deficient rat (SDR) (mean ALT 30 IU/L vs. 12 IU/L; mean AST 250 IU/L vs. 100 IU/L) ↓ CPT-1, ↑ expression of enzymes for triglyceride synthesis↑ Oxidative stress markers in SDR compared with those in the control GH and/or IGF-I administration improved all these changes