ESR1 and breast carcinoma: The rs2046210 genotype was significantly associated with the cumulative incidence of breast cancer by age in ER-positive (p = 0.013, log-rank test), luminal (p = 0.010) and luminal A patients (p = 0.022), but not in unselected (p = 0.205) or ER-negative patients (p = 0.164; Figure 1 and Figure S1).