Autophagy inhibition by Beclin1 silencing inhibits Notch1 degradation, increases breast cancer cell migration [68] and ERβ (known to act as a tumor suppressor in breast cancer), transactivates claudin-6 (CLDN6), and induces CLDN6-related autophagy to suppress migration and invasion in breast cancer [69]. The gene discussed is NOTCH1; the disease is breast cancer.