NOTCH1 and neoplasm: In contrast, the role of autophagy in tumor suppression includes maintaining cellular homeostasis (which is also relevant to human epidermal growth factor receptor 2 (HER-2) pathway inhibition), Wnt family member 1 (WNT1) pathway inhibition, Bcl2 inhibition, neurogenic locus notch homolog protein 1 (Notch1) degradation, and forkhead box O3 (FOXO3) signaling [45].