Nevertheless, we should take into consideration that inadequate vitamin D levels have been correlated with higher MS risk and disease activity [52], whereas the role of IL-1β in the pathophysiology of MS is well recognized; in the experimental model of autoimmune encephalomyelitis, autoreactive Th1 and Th17 cells enhance IL-1β production, thus promoting neuroinflammation and CNS damage [53,54]. The gene discussed is IL1B; the disease is myeloid sarcoma.