On the other hand, in experimental models, it has been shown that the absence of an enzyme that reduces peroxides with a preserved cysteine residue and protects OxS cells called peroxirredoxin-6 (PRDX6) (Prdx6−/− mice), induced T2DM, dramatically reduced the telomeric length with increased activity of senescence-associated beta-galactosidase (SA-β-gal) (biomarker for aging and senescent cells), and decreased nuclear-cytoplasmic transport of SIRT1 (important enzyme for the replacement of defective mitochondria). The gene discussed is PRDX6; the disease is type 2 diabetes mellitus.