PNPLA3 and hepatocellular carcinoma: Likewise, genetic predispositions may also influence the progression of NAFLD up to HCC [17], and the rs738409 single nucleotide polymorphism (SNP) in the patatin-like phospholipase domain-containing 3 (PNPLA3) gene is the most studied genetic predictor of NAFLD-HCC [18], although several other genetic variants are under evaluation [10].