Furthermore, lncRNAs such as nuclear paraspeckle assembly transcript 1 (NEAT1), hox transcript antisense RNA (HOTAIR), metastasis-associated lung adeno-carcinoma transcript 1 (MALAT1), and HOXA distal transcript antisense RNA (HOTTIP) are upregulated and play a role in the progression of liver fibrosis and hepatocellular carcinoma [23]. This evidence concerns the gene HOTTIP and hepatocellular carcinoma.