CHRFAM7A and brain ischemia: Probably, the increase in oxidative stress is the main factor responsible for this change, since regardless of the group analyzed, in all sessions where the aerobic stimulus was present (AE and CE), there was an increase in the expression of CHRFAM7A. Interestingly, acute diseases and conditions that generate high oxidative stress and reactive oxygen species (COVID-19, brain ischemia, lung injury, LPS exposure and skin burn) exert similar effects [16,17,18,38].