As exercise effects on gene expression may vary according to the energetic expenditure, sympathetic activation, muscle damage and blood factors such as oxidative stress during the session, we also aim to compare the effects of different types of exercise on the expression of TNF-α, CHRNA7 and CHRFAM7A genes in leukocytes of overweight individuals with T2DM (OT2D) and healthy normal weight individuals (HNW). Here, CHRFAM7A is linked to type 2 diabetes mellitus.