C1QTNF1 and coronary artery disorder: For example, CTRP9 abundance in the serum is reduced in diabetic mice or after ischemia/reperfusion (I/R) injury or increased in response to chronic pressure overload; CTRP3 levels are decreased in patients with coronary artery disease (CAD) whereas CTRP1 levels are increased in CAD and correlate with blood pressure and blood lipids [31,45,46,47,48].