Inconsistent with these potential effects of Mint3 on the immune system, a previous report from the group of Huai [66] showed that Mint3 potentiates an antiviral response through the expression of IFN-β upon the induction of immune signals after viral infection or LPS stimulation through Toll-like receptors (TLRs) and retinoic acid-inducible gene-I–like receptors (RLRs) [67,68,69,70]. Here, APBA3 is linked to viral infectious disease.