For MIBC, recent forays into multi-genomic approaches using weighted-gene network analyses have indicated CLK4, DEDD2, ENO1, and STYL1 as genes of interest in addition to Lynch syndrome-associated and checkpoint-associated genes (FGFR3, PIK3CA, TERT, p53, MSH2, MSH6, MLH1, and PMS2) [3,5,8,73]. The gene discussed is MSH2; the disease is Lynch syndrome.