Thus, five pathogenic human mtDNA mutations were selected to create D. rerio models of mitochondrial diseases with mutations such as m.8363G > A (MT-TK), m.3733G > A (MT-ND1), m.13513G > A (MT-ND5), m.12276G > A (MT-TL1) and m.3376G > A (MT-ND1), which have been associated with MERRF-like syndrome, MELAS, cardiomyopathy, LHON, Leigh syndrome and CPEO [143,144,145,146,147]. This evidence concerns the gene MT-ND5 and Leigh syndrome.