ACVR1 and neoplasm: Genomic analyses have revealed that DMGs are molecularly complex, also harbouring mutations in ACVR1, ATRX, H3F3A, HIST1H3B/c, MYC, PDGFRA, PIK3CA, PTEN, and RB1 that can cooperate with mutated TP53 and PPM1D to promote tumour formation [2,6,7,8,9].