SERPINA1 and COVID-19: Recent studies have demonstrated that A1AT is an inhibitor of SARS-CoV-2 infection and two of the most important proteases in the pathophysiology of COVID-19: transmembrane serine protease 2 and the disintegrin and metalloproteinase 17, as was well as an inhibitor of inflammatory molecules, such as IL-8, TNF-α, and neutrophil elastase [8,9].