During the COVID-19 pandemic, several epidemiologic studies have reported that the geographical distributions of the prevalence of SERPINA1 allelic variants and severe cases of COVID-19 were similar, although confounding factors should be considered in these analyses, such as the different control measures established by governments, SARS-CoV-2 vaccination, socioeconomic status, and population health [3,7,15]. The gene discussed is SERPINA1; the disease is COVID-19.