By analyzing the potential associations between AS, aortic elasticity, and some parameters defining DD and factors related to the severity of the SARS-CoV-2 infection, we evidenced powerful statistically significant correlations between the PWV, AoS, AoSI, E/e’, and TRV and the time elapsed since COVID-19 diagnosis, the amplitude of the infection described by the severity of the lung injury, the initial level of CRP, and the intensity of the post-acute COVID-19 syndrome, namely, the number of persistent symptoms, and the PCFS scale. This evidence concerns the gene CRP and COVID-19.