SNCA and Parkinson disease: Synaptic dysfunction is indeed found in early stages of PD neuropathology and is mediated by apparent pathological elevation of Alpha-synuclein (SNCA), a PD-implicated protein that is central to the synaptic dystrophy that precedes dopaminergic cell loss [7], whose dysfunction contributes to synaptic failure [8], affirming the classification of PD as a synaptopathy [9].