SNCA and Parkinson disease: Whereas SNCA is a presynaptically active protein that is causally linked to Parkinson’s disease through its role in the biosynthesis, release, and reuptake of dopamine [11], CaMKIIa is an important kinase that is enriched in mammalian synapses and plays critical roles in modulating synaptic transmission, which has also been found to interact with the dopamine receptor and thus play a role in PD pathogenesis (Table 1) [2,12].