Now, using mass spectrometry coupled with the isobaric tag for relative and absolute quantitation (iTRAQ) method, we quantified proteome-wide effects of PHF8 depletion in primary cortical neurons stimulated using a combination of three pharmacological agents to induce chemical LTP [66,67] and report that PHF8 may play a regulatory role in the activity-induced expression of neuronal proteins such as Alpha-synuclein and Calmodulin Kinase II Alpha, which in turn play critical roles in the function of neuronal synapses and the pathophysiology of PD. This evidence concerns the gene SNCA and Parkinson disease.