Finally, the current proteomic dataset also shows that PHF8 affects the levels of three more PD-linked synaptic proteins: DNAJC6, which is implicated in synaptic vesicle trafficking and clathrin dynamics and is genetically associated with PD [17]; its functionally linked protein SYNJ1, which is involved in synaptic vesicle recycling [18]; and yet another endosomal protein SH3GL2, which may play a role in PD pathogenesis through its regulation of synaptic vesicle endocytosis [10]. The gene discussed is SH3GL2; the disease is Parkinson disease.