In particular, Karen–Shaul et al., identified two clusters of DAM, clusters II (4.2%) and III (2.8%), whose transcriptional profile was characterized by the downregulation of microglial homeostatic genes, such as the purinergic receptors P2ry12/P2ry13, Cx3cr1, and Tmem119, and upregulation of key AD risk factor genes, including ApoE, Ctsd, Lpl, Tyrobp, and Trem2 [56]. This evidence concerns the gene LPL and Alzheimer disease.