Recently, Zhu et al. determined that the downregulation of HERC5 in human CRC attenuated its ubiquitination degradation of CtBP1, which inhibits apoptotic signaling by assembling into a transcriptional complex with HDAC1 and c-MYC, ultimately promoting the development of CRC [72]. This evidence concerns the gene HERC5 and colorectal carcinoma.