In addition, SMURF1 was reported to be transcriptionally activated by FOSL1, which aggravates SMURF1-induced ubiquitination and degradation of FBXL2, resulting in the induction of WNT/β-catenin signaling to potentiate EMT, proliferation, and metastasis of CRC [55]. The gene discussed is SMURF1; the disease is colorectal carcinoma.