According to the cluster analysis heat map of apoptosis, the protein expression in the ALL treatment group was similar to that of the control group, which was distinct from the DSS stimulation, such as caspase 3, caspase 7, Prkar1a, Tradd, Cycs, Bcl2, Chuk, Akt2, Rela, etc. Interestingly, Akt1 and Akt2 from the DSS and ALL groups presented opposite trends in the apoptosis signaling pathway, and the Akt2 condition from the ALL group presented a similar trend to the control, unlike the DSS group. Here, PRKAR1A is linked to acute lymphoblastic leukemia.