The PI3K-AKT signaling pathway, apoptosis, Alzheimer’s disease, and chemokine signaling pathway were all among the top 50 signaling pathways, as shown in Figure 1C. Then, the intersecting targets were imported into the STRING database for protein–protein interaction analysis, and the results were imported into Cytoscape 3.7.2 software to map the PPI network. The gene discussed is PIK3CA; the disease is early-onset autosomal dominant Alzheimer disease.