MAPK3 and acute lymphoblastic leukemia: In the heat map of a chemokine signaling pathway (Figure 7A), ALL is shown to reduce the protein levels of Mapk3, Prkacb, Crk, Rock2, Csk, Grb2, Gnb5, Rac1, Gnb1, Rela, and Chuk, which were increased by DSS; however, ALL upregulated Akt1, Stat3, Rock1, Dock2, Gnb2, and Stat1.